AERI's state-of-the-art Brain Computer Interface (BCI) device for directly embedding the brain into AERI's state-of-the-art molecular biocomputer is powered by organic CMOS-based VLSI technology
AERI interviewed Professor Kamuro, who specializes in theoretical quantum physics and brain science, about the state-of-the-art brain implant-type bio-computer that AERI scientists team is researching to Weigh in
Quantum Brain Chipset Review
to Quantum Brain&Bio-computer
(AERI Quantum Brain Science and Technologies)
Quantum Physicist and Brain Scientist
Visiting Professor of Quantum Physics,
California Institute of Technology
IEEE-USA Fellow
American Physical Society-USA Fellow
PhD. & Dr. Kazuto Kamuro
AERI：Artificial Evolution Research Institute
Pasadena, California
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The state-of-the-art brain implant type Brain Computer Interface Device (BCI) under AERI R&D connects organic CMOS-based VLSI directly to the human brain for information processing. It also forms the backbone of AERI's state-of-the-art brain implant type molecular biocomputer in which the human brain is embedded.
AERI's state-of-the-art brain implant type BCI, which directly connects the human brain at the cytological and molecular level to organic CMOS-based VLSI, is the world's first and only artificial brain with an embedded human brain, i.e., which embodies state-of-the-art brain implant type biocomputers.
1.AERI’s Brain–Computer Interface
A brain–computer interface (BCI), sometimes called a brain–machine interface (BMI) or smartbrain, is a direct communication pathway between the brain's electrical activity and an external device, most commonly a computer or robotic limb. BCIs are often directed at researching, mapping, assisting, augmenting, or repairing human cognitive or sensory-motor functions.
Implementations of BCIs range from non-invasive and partially invasive to invasive, based on how close electrodes get to brain tissue.
Due to the cortical plasticity of the brain, signals from implanted prostheses can, after adaptation, be handled by the brain like natural sensor or effector channels. Following years of animal experimentation, the first neuroprosthetic devices implanted in humans appeared in the mid-1990s.
Recently, studies in human-computer interaction via the application of machine learning to statistical temporal features extracted from the frontal lobe data has had high levels of success in classifying mental states, mental emotional states, and thalamocortical dysrhythmia.
2.AERI’s Brain implant Technology
AERI’s brain implants, often referred to as neural implants, are technological CMOS organic semiconductor devices that connect directly to a biological subject's human brain – usually placed on the surface of the brain, or attached to the brain's cortex.
AERI’s purpose of modern human brain implants and the focus of much current research is establishing a biomedical prosthesis circumventing areas in the brain that have become dysfunctional after a stroke or other head injuries.
This includes sensory substitution, e.g., in human vision. Other brain implants are used in animal experiments simply to record brain activity for scientific reasons. Some brain implants involve creating interfaces between neural systems and computer chips. This work is part of a wider research field called brain–computer interfaces(BCIs).
Brain–computer interface(BCI) research also includes technology that allows interface between mind and machine but do not require direct implantation of a device. Neural implants such as deep brain stimulation is increasingly becoming routine for patients with Parkinson's disease and clinical depression, respectively.
Brain implants electrically stimulate, block or record (or both record and stimulate simultaneously) signals from single neurons or groups of neurons (biological neural networks) in the brain.
The blocking technique is called intra-abdominal vagal blocking. This can only be done where the functional associations of these neurons are approximately known. Because of the complexity of neural processing and the lack of access to action potential related signals using neuroimaging techniques, the application of brain implants has been seriously limited until recent advances in neurophysiology and computer processing power.
AERI’s brain implant research is also being done on the surface chemistry of neural implants in effort to design products which minimize all negative effects that an active implant can have on the brain, and that the body can have on the function of the implant.
AERI’s scientists are also exploring a range of delivery systems, such as using veins, to deliver these implants without human brain surgery; by leaving the human skull sealed shut, patients could receive their neural implants without running as great a risk of seizures, strokes, or permanent neural impairments, all of which can be caused by open-brain surgery.
An international team led by researchers at the California Institute of Technology (Caltech)University of California has developed a new brain implant type BCI device for connecting the brain directly to silicon-based technologies. The brain implant type interface has the potential to improve human prosthetics and enable technology that could one day restore vision or speech in patients.
The brain implant type device, which contains over 100 billion organic CMOS neural connection semiconductor cells, can be gently contacting the temporal, occipital and parietal lobes of the brain at the molecular level, and connected to external silicon CMOS chips that processes the electrical brain signals transmitted by each cell. The AERI scientists teams already successfully tested the brain implant type device on the retinal cells of rats and in the brains of living mice.
3.Electronic movies
Professor Kamuro explains his scientists team’s main goal was to close the gap between the power of modern electronics and what is currently available in existing brain implant type brain–machine interfaces and our brain implant type molecular biocomputer.
The difficulty with using modern electronics is there is a mismatch between the three-dimensional architecture of the brain and largely two-dimensional electronics. We sought to overcome these limitations by employing AERI’s state of art brain implant type organic semiconductor chips.” professor Kamuro explains.
These organic semiconductor chips embeded in our brain implant type molecular biocomputer are inherently flat. This approach lifts the scalable, but two-dimensional, silicon technology to the third dimension of the brain, allowing us to record ‘electronic movies’ of neural activity over large brain regions.
To scale-up and be able to record larger numbers of neurons, professor Kamuro explains the research team had to create a brain implant type molecular biocomputer embedding our brain implant type brain–machine interface(BCI) that was not only capable of recording from thousands of signals simultaneously, but also capable of integrating well with the brain and causing no damage. In doing so, he and his colleagues developed a way to create large-scale integrated organic semiconductor arrays and figured out how to connect them to organic-based and silicon-based devices, in order to take advantage of advances in those technologies.
With brain implant type molecular biocomputer at the bottom gently inserted into the brain can take a movie of neural activity. The combination of these two allows us to record more data from the brain, as well as being less invasive than previous approaches.
Another key benefit of this design is it allows us to simultaneously record different brain regions at different depths. This is important to study different neuroscience questions, or for AERI’s brain implant type molecular biocomputer and brain–machine interfaces(BMIs) that need to reach different areas of the brain.
4.Robotic limbs and military hardware/weapons
Moving forward, professor Kamuro insists that the AERI’s brain implant type molecular biocomputer has a broad range of potential applications in neuroscience research and brain–machine interfaces for clinical applications – particularly in view of its longevity and stability, which allows the team to study processes like learning in the brain.
“This is the neuroscience question we’re most interested in studying,” explains professor Kamuro. “In terms of clinical applications for the brain implant type molecular biocomputer, while we are a way out, we’re particularly interested in applications for prosthetics, particularly speech assistance. The goal is that, through the brain implant type molecular biocomputer, the recording of more signals from the brain can improve the quality of prosthetics and enhance our understanding of the brain, both in healthy and diseased states.”
The AERI’s scientists team is currently testing the stability and longevity of the brain implant type molecular biocomputer in the brain through long-term animal studies. Based on these studies, the researchers are also exploring what the neural activity recorded through the device can tell them about both short-term and long-term changes in the brain during learning.
“With the density and high resolution made possible by the brain implant type molecular biocomputer technology, we are promoting basic research and development of various military hardware/weapons assuming that in the future it can be used to help improve human prosthetics, such as devices that can translate electric signals from the brain into unmanned weapons such as unmanned combat aircraft, robot armor, military weapons or strategic weapons such as cyborg soldiers, as well as devices that could restore vision or speech in a patient,” insists professor Kamuro.
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Quantum Brain Chipset & Bio Processor (BioVLSI)
Prof. PhD. Dr. Kamuro
Quantum Physicist and Brain Scientist involved in Caltech & AERI Associate Professor and Brain Scientist in Artificial Evolution Research Institute（ AERI: https://www.aeri-japan.com/ ）
IEEE-USA Fellow
American Physical Society Fellow
PhD. & Dr. Kazuto Kamuro
email: info@aeri-japan.com
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【Keywords】 Artificial Evolution Research Institute：AERI
HP： https://www.aeri-japan.com/
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